10 Common Medications Linked to Angioedema
Angioedema is a sudden swelling of the deeper layers of the skin, often around the eyes, lips, and throat. It can be life-threatening if it affects breathing. While various factors can trigger angioedema, medications are one of the most common culprits.
1. ACE Inhibitors (Lisinopril, Enalapril, Ramipril)
Used to treat high blood pressure and heart failure, ACE inhibitors are one of the most frequent causes of drug-induced angioedema. This reaction can occur even after years of use.
2. Angiotensin II Receptor Blockers (ARBs) (Losartan, Valsartan, Irbesartan)
Although ARBs are considered safer than ACE inhibitors, they can still cause angioedema in some individuals. The risk is lower but still significant.
3. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (Ibuprofen, Naproxen, Aspirin)
NSAIDs are commonly used for pain relief, but they can trigger angioedema, especially in people with a history of allergic reactions or asthma.
4. Beta-Blockers (Metoprolol, Propranolol, Atenolol)
These heart and blood pressure medications can contribute to angioedema by interfering with the body's natural ability to control swelling and allergic reactions.
5. Antibiotics (Penicillin, Amoxicillin, Sulfa Drugs)
Some antibiotics can cause severe allergic reactions, including angioedema. People with a history of antibiotic allergies should be especially cautious.
6. Aspirin and Antiplatelet Drugs (Clopidogrel, Ticagrelor)
While used to prevent blood clots, these medications can also trigger swelling reactions, particularly in people sensitive to NSAIDs.
7. Diuretics (Hydrochlorothiazide, Furosemide, Spironolactone)
Commonly used to reduce fluid retention and lower blood pressure, diuretics have been linked to angioedema, though the reaction is relatively rare.
8. Opioids (Codeine, Morphine, Tramadol)
Certain painkillers can cause histamine release, leading to swelling and allergic reactions, including angioedema.
9. Monoclonal Antibodies and Biologics (Infliximab, Etanercept, Adalimumab)
Used to treat autoimmune diseases, these advanced drugs can sometimes cause severe allergic reactions, including angioedema.
10. Contrast Dyes Used in Medical Imaging
Though not technically a medication, contrast agents used in CT scans and MRIs can cause angioedema, especially in people with a history of drug allergies.
