These small, inflamed ulcers may seem minor, but for the millions who deal with them regularly, they can seriously disrupt daily life. The good news? 2025 has brought a wave of breakthrough treatments — and some of them are surprisingly effective.

We combed through new clinical findings, trending therapies, and expert recommendations to find out what actually works. Here are the top 7 canker sore treatments making headlines this year.

1. Zinc-Based Healing Gels

Zinc has long been known for its immune-supporting properties, but new topical gels infused with zinc and amino acids are proving highly effective at reducing healing time by up to 40%. Users report faster relief and reduced inflammation within 24 hours of application.

2. Red Light Therapy (RLT) Pens

Originally used for skin care and muscle recovery, low-level red light therapy is now being harnessed in compact, FDA-cleared devices for mouth ulcers. Just 60 seconds of treatment twice a day has shown promising results — accelerating healing and dulling pain without the need for medication.

3. Aloe Vera Mouth Rinses (New Formulations)

Aloe has been a go-to for generations, but new research-backed mouth rinse formulations combine aloe with antiseptic herbal extracts. The result? A soothing rinse that calms irritation while reducing bacterial growth — ideal for frequent sufferers.

4. Prescription-Strength Barrier Patches

These new bioadhesive patches create a micro-protective layer over the sore, shielding it from irritation while delivering active ingredients like corticosteroids and analgesics. Think of it like a Band-Aid for the inside of your mouth — game-changer.

5. Hydrogen Peroxide Microfoam (OTC)

Forget the old-school swish-and-burn. The latest OTC microfoam products deliver hydrogen peroxide in a gentle foam that cleanses the sore and promotes tissue repair — all without stinging like traditional rinses.

6. Lysine + Vitamin B12 Daily Regimens

Preventative care is getting smarter. New clinical trials show that a consistent combo of lysine and B12 can significantly reduce recurrence rates in chronic sufferers. Think of it as a daily immune boost specifically targeting oral ulcers.

7. CBD Oral Sprays with Antiseptic Compounds

Yes, CBD made the list — but it’s not just hype. The newest formulations combine anti-inflammatory cannabinoids with clove oil and xylitol, creating a powerful pain-reducing spray that works within minutes and fights off secondary infections.