We tend to associate drowsiness with cold medicine or prescription sedatives, but there are plenty of everyday medications that can make you tired — even if they’re not labeled that way. The effects are subtle, sneaky, and often mistaken for stress or lack of sleep.

Here are five common culprits that might be draining your energy levels — without you even realizing it.

1. Antihistamines (Even the “Non-Drowsy” Kind)

Used for allergies, hives, and sinus issues, antihistamines like loratadine or cetirizine are everywhere. While many are labeled “non-drowsy,” some people are more sensitive and still experience fatigue. Plus, if you're doubling up on allergy relief (think pills and nasal sprays), the sedative effects can stack up.

2. Blood Pressure Medications

Beta blockers and calcium channel blockers are essential for heart health, but they can slow your heart rate and lower adrenaline — which often leads to sluggishness. Some people report brain fog, exhaustion, and reduced stamina within days of starting these meds.

3. Antidepressants

Ironically, medications prescribed to boost mood can sometimes blunt your energy. SSRIs and tricyclic antidepressants can interfere with REM sleep or lower motivation during the day, especially in the early weeks of use. For many, the fatigue improves — but for others, it lingers.

4. Pain Relievers (Especially Opioids)

We’re not just talking about heavy-duty prescriptions — even over-the-counter painkillers can have energy-zapping effects, especially if taken frequently. Opioids like codeine and hydrocodone directly depress the central nervous system and can leave you groggy for hours.

5. Heartburn & Acid Reflux Meds

Proton pump inhibitors (PPIs) like omeprazole and lansoprazole are super common — but did you know long-term use can interfere with vitamin B12 absorption? A B12 deficiency can cause tiredness, weakness, and even memory issues.