Most people chalk up fatigue to age, stress, or poor sleep. But what if the real reason is the pills you take every day?

The Hidden Energy Drains in Common Medications

From antihistamines to heartburn meds, dozens of common prescriptions and over-the-counter drugs list “fatigue” as a side effect. You might be taking one—or more—without realizing the impact they’re having on your energy, metabolism, or mental clarity.

For example, beta-blockers used for blood pressure can slow your heart rate and leave you feeling sluggish. Antidepressants—especially SSRIs—can lead to chronic fatigue in some people. Even sleep aids, iron supplements, and allergy medications can cause next-day drowsiness, especially as your body changes with age.

Many people 40+ are on multiple medications that interact, compounding these effects. It’s not always about the drug itself, but how your body metabolizes it as you age.

Why Age Makes a Difference

As we grow older, our liver and kidney function changes. Medications may stay in our systems longer, or process differently than they used to. That harmless sleep aid you took in your 30s? It might be knocking you out in your 40s—and dragging your energy down all day.

Compounding the issue: many adults are told their fatigue is just part of getting older. But feeling exhausted all the time isn’t normal—it’s a signal something needs attention.

What You Can Do (That Most People Don’t Know)

✅ Check your medications: Look up the side effects, or ask your pharmacist about fatigue or drowsiness risks.

✅ Get a full medication review: A growing number of clinics and telehealth services now offer reviews that focus on energy, mood, and aging.

✅ Ask about alternatives: In many cases, there are newer or more targeted options that don’t come with the same draining side effects.

One of the most overlooked causes of chronic tiredness in people over 40 is prescription fatigue. But once you understand it, you can take back control of your energy—and your life.