If you’ve ever worried about your heart health — this could change everything.
Most people have never heard of lipoprotein(a), or Lp(a). But if you have high levels, you could be at greater risk of heart attack or stroke — even if your cholesterol is “normal.” Here’s the kicker: diet and exercise won’t bring it down. Until recently, there was virtually no treatment that could significantly lower Lp(a).
But now, something is changing.
A new investigational therapy called lepodisiran is making headlines in the medical world — and for good reason. In early studies, this RNA-based drug was shown to dramatically reduce Lp(a) levels, potentially opening the door to a brand-new way of preventing heart disease.
Doctors are calling it a “silent revolution” in cardiovascular medicine.
So what makes lepodisiran different?
It doesn’t just treat the symptoms. It goes deeper — straight to the genetic instructions that cause the body to make Lp(a) in the first place. By silencing that production at the RNA level, it may help millions of people genetically predisposed to heart problems.
And the results so far?
In a recent trial, participants given lepodisiran saw Lp(a) levels plummet by more than 90% — with effects lasting months after just a single dose.
For people with a family history of early heart disease or elevated Lp(a), this could be a game-changer. While the treatment is still in clinical trials, its potential has many experts feeling hopeful.
“This could become the first real therapy for a genetic risk factor we've had no control over — until now,” says one cardiologist.
So, how do you know if you’re affected?
Most standard cholesterol tests don’t measure Lp(a) — so you’d have to ask your doctor specifically. The good news? A simple blood test can tell you.
