1. ACE Inhibitors (Lisinopril, Enalapril, Ramipril)

ACE inhibitors, commonly prescribed for high blood pressure and heart conditions, are a leading cause of drug-induced angioedema. This reaction can occur months or even years after starting the medication, making it especially dangerous for seniors.

2. Angiotensin II Receptor Blockers (Losartan, Valsartan, Irbesartan)

While these drugs are often considered alternatives to ACE inhibitors, they can also trigger angioedema in some patients, particularly those who previously experienced reactions to ACE inhibitors.

3. NSAIDs (Ibuprofen, Naproxen, Aspirin)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for arthritis and pain relief. However, they can provoke angioedema, especially in individuals with a history of allergic reactions or asthma.

4. Diuretics (Hydrochlorothiazide, Furosemide, Spironolactone)

Diuretics help manage conditions like high blood pressure and heart failure by reducing fluid retention. However, some patients develop angioedema due to increased sensitivity to these medications.

5. Penicillin and Other Antibiotics

Some antibiotics, particularly penicillins and cephalosporins, can cause angioedema in individuals with drug allergies. If you’ve ever had an allergic reaction to an antibiotic, notify your doctor before starting any new prescription.

6. Blood Thinners (Warfarin, Heparin, Apixaban)

While blood thinners reduce the risk of stroke and blood clots, they can also lead to swelling issues, especially in those prone to allergic reactions.

7. Gliptins (Sitagliptin, Linagliptin, Saxagliptin)

These diabetes medications, known as DPP-4 inhibitors, have been associated with angioedema, particularly in patients also taking ACE inhibitors.