A Skin Condition That Deserves Better Answers

Psoriasis affects more than 8 million people in the U.S. alone. While it can be genetic or triggered by stress and immune system irregularities, the impact is deeply personal. The itchiness, cracking, and inflammation can make everyday life uncomfortable. That’s why people often turn to over-the-counter creams before committing to more aggressive treatments.

But in a market flooded with options, patients are increasingly skeptical. “I’ve tried everything,” says one reviewer. “But only one cream ever made a noticeable difference.” So which formulas are making waves—and why?

1. Clobetasol Propionate (Brand: Temovate, Clobex)

Prescription-only | Fast anti-inflammatory action

Clobetasol is one of the strongest topical corticosteroids prescribed for moderate to severe plaque psoriasis. It works fast by suppressing inflammation, reducing redness and itching almost immediately. Available in creams, foams, and sprays, it's ideal for thick plaques on elbows, knees, and scalp.

Why patients love it: Many report visible clearing within days. But it should only be used short-term due to potency.

2. Calcipotriene (Brand: Dovonex)

Prescription-only | Vitamin D analog

This synthetic form of vitamin D slows down skin cell overproduction — one of the core causes of psoriasis plaques. It’s not a steroid, so it’s gentler for long-term use. Often combined with betamethasone for enhanced effect.

Why patients love it: Less irritation than steroids, and safe for daily use on chronic patches.

3. Hydrocortisone 2.5% Cream

OTC & Rx strength | Mild corticosteroid

While less potent than clobetasol, hydrocortisone 2.5% is often enough for mild cases or sensitive areas like the face or folds of skin. It’s widely available and affordable, making it a go-to for many.

Why patients love it: It’s easy to find, affordable, and helps calm smaller flare-ups quickly.

4. CeraVe Psoriasis Moisturizing Cream

Over-the-counter | Skin barrier support

This non-prescription favorite contains salicylic acid (to soften plaques), urea, lactic acid, and niacinamide. It doesn’t replace prescription meds for serious cases, but it excels at restoring skin moisture and reducing itch.

Why patients love it: Gentle, fragrance-free, and approved by the National Psoriasis Foundation.

5. MG217 Psoriasis Medicated Multi-Symptom Cream

Over-the-counter | Coal tar-based

Coal tar may sound old-school, but it’s still effective. MG217’s cream uses 2% coal tar to slow rapid skin cell turnover and reduce inflammation. It’s great for stubborn plaques, especially on knees, elbows, and feet.

Why patients love it: Thick, long-lasting formula that provides relief overnight. NPF Seal of Recognition approved.

6. Tazarotene (Brand: Tazorac)

Prescription-only | Topical retinoid

Derived from vitamin A, this cream helps thin psoriasis plaques and reduce inflammation by regulating skin cell growth. It’s often combined with corticosteroids for more aggressive treatment plans.

Why patients love it: Particularly effective for scalp and nail psoriasis, and works well long-term with minimal steroid use.

7. Eucerin Roughness Relief Lotion (With Urea)

Over-the-counter | Moisturizer for dry, scaly skin

While not a medication, Eucerin's formula with 10% urea helps soften thickened patches and maintain hydration — crucial for people with psoriasis. Often used alongside medical treatments to maximize comfort.

Why patients love it: Non-greasy, fragrance-free, and reduces tightness during flares.

8. Tacrolimus Ointment (Brand: Protopic)

Prescription-only | Calcineurin inhibitor

Originally designed for eczema, Protopic has shown success in treating psoriasis in sensitive areas (like eyelids or genitals) where steroids may be too harsh. It reduces immune activity and inflammation without thinning the skin.

Why patients love it: Great for delicate areas and long-term flare control without steroid risks.

⚠️ What to Know Before You Choose a Cream

Potency matters: Stronger isn’t always better. Mild creams may work well for sensitive spots, while thick plaques might require prescription steroids.

Layering is key: Many dermatologists recommend using a prescription at night and a moisturizer during the day.

Watch for irritation: Retinoids and coal tar can cause peeling or stinging—start slow.

Always follow up: If creams stop working or cause side effects, consult a dermatologist. Adjusting treatment early can prevent worsening symptoms.